Hydrochloric Acid → HCID 178521765, 화합물

HRID 1163390

반응식

HRID 1163390 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:33]([C:34](=[O:45])[NH:35][C:36]3[CH:44]=[C:43]4[C:39]([CH:40]=[N:41][NH:42]4)=[CH:38][CH:37]=3)=[CH:32][C:17]3[N:18]=[C:19]([NH:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[C:28]([F:31])([F:30])[F:29])[NH:20][C:16]=3[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[NH:42]1[C:43]2[C:39](=[CH:38][CH:37]=[C:36]([NH:35][C:34]([C:33]3[C:14]([N:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[CH:15][C:16]4[NH:20][C:19]([NH:21][C:22]5[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=5[C:28]([F:29])([F:30])[F:31])=[N:18][C:17]=4[CH:32]=3)=[O:45])[CH:44]=2)[CH:40]=[N:41]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 178452214HCID 178452214, 화합물

생성물 1

HCID 178521765HCID 178521765, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

The product from Example 87 was treated with 4M HCl in dioxane employing the procedure described for Example 80 to afford of 6-piperazin-1-yl-2-(2-trifluoromethylphenylamino)-1H-benzimidazole-5-carboxylic acid (1H-indazol-6-yl)-amide as a hydrochloride salt. MS: m/z 521 (M+H)+.

출처 및 근거

ORD 기록
ord-680a097875c94309ad1dbc413cff7efd
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820821B2

연결된 노트

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