Sodium Chloride → 2-[2-Methoxy-3-(o-tolylthio)phenyl]acetonitrile

HRID 1164110노트

반응식

HRID 1164110 반응식
[C-:1]#[N:2].[Na+].[CH3:4][O:5][C:6]1[C:11]([CH2:12]Cl)=[CH:10][CH:9]=[CH:8][C:7]=1[S:14][C:15]1[C:16]([CH3:21])=[CH:17][CH:18]=[CH:19][CH:20]=1.[Cl-].[Na+]>CS(C)=O>[CH3:4][O:5][C:6]1[C:7]([S:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])=[CH:8][CH:9]=[CH:10][C:11]=1[CH2:12][C:1]#[N:2]

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 8929Sodium CyanideHCID 20513475o-Tolyl 2-methoxy-3-chloromethylphenyl thioether

생성물 1

HCID 205134502-[2-Methoxy-3-(o-tolylthio)phenyl]acetonitrile수율 96%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Powdered sodium cyanide (1.5 g) was added all at once to a solution of o-tolyl 2-methoxy-3-chloromethylphenyl thioether (8.3 g) in dimethyl sulfoxide (40 ml), and the mixture was stirred for 15 minutes, poured into saturated aqueous solution of sodium chloride and extracted with diethyl ether. The extract was washed with water, dried and then evaporated under reduced pressure to give oily 2-[2-methoxy-3-(o-tolylthio)phenyl]acetonitrile (7.7 g).

후처리

  1. extractionextracted with diethyl ether
  2. washThe extract was washed with water
  3. customdried
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ab22cb2c452e459a9e128506dbf3af59
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04367238

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