1,4-Dibromobutane → 3-(4-Bromobutyl)-1,3-thiazolidine-2,4-dione
반응식
[Na].[S:2]1[CH2:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[Br:9][CH2:10][CH2:11][CH2:12][CH2:13]Br>CN(C)C=O>[Br:9][CH2:10][CH2:11][CH2:12][CH2:13][N:4]1[C:5](=[O:7])[CH2:6][S:2][C:3]1=[O:8]참가 물질
4
실험 절차
The 2,4-thiazolidinedione sodium salt (13.91 g., 0.1 mole) is added to a solution of 1,4-dibromobutane (64.77 g., 0.3 mole) in 500 ml. of dry dimethylformamide. After stirring the mixture at room temperature for a 16 hr. period, the resulting clear solution is concentrated in vacuo and residual material dissolved in chloroform, filtered, and concentrated in vacuo to an amber oil. Distillation of the oil affords 20.62 g. (81% yield) of 3-(4-bromobutyl)-2,4-thiazolidinedione, b.p. 105°-115° C. at 0.02 mmHg.
후처리
- concentrationperiod, the resulting clear solution is concentrated in vacuo and residual material
- dissolutiondissolved in chloroform
- filtrationfiltered
- concentrationconcentrated in vacuo to an amber oil
- distillationDistillation of the oil
- customaffords 20.62 g
출처 및 근거
- ORD 기록
- ord-36630187808c40098768ea1fe11b59f3
- 출처 데이터셋
- uspto-grants-1983_01
- 특허 번호
- US04367335
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