Sodium Chloride → 4-(1-Pyrrolyl)-2-indanyl acetate

HRID 1164209

반응식

HRID 1164209 반응식
[C:1]([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:14])[CH2:6]1)(=[O:3])[CH3:2].CO[CH:17]1[CH2:21][CH2:20][CH:19](OC)O1.C(Cl)(Cl)Cl.[Cl-].[Na+]>C(O)(=O)C>[C:1]([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[N:14]2[CH:17]=[CH:21][CH:20]=[CH:19]2)[CH2:6]1)(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 5234Sodium ChlorideHCID 6212ChloroformHCID 790982,5-DimethoxytetrahydrofuranHCID 132395844-amino-2,3-dihydro-1H-inden-2-yl acetate

생성물 1

HCID 132395854-(1-Pyrrolyl)-2-indanyl acetate수율 92.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A stirred solution of 0.70 g (0.004 mole) of 4-amino-2-indanyl acetate and 0.56 g (0.004 mole) of 2,5-dimethoxytetrahydrofuran in 1.5 mL of acetic acid was heated under reflux for 3 hours. The reaction mixture was cooled to ambient temperature and poured into 30 mL of chloroform. The mixture was stirred with 30 mL of an aqueous saturated solution of sodium chloride. The organic layer was removed, and the aqueous layer extracted with two portions of 30 mL each of chloroform. The combined organic phases were washed with two portions of 30 mL each of an aqueous saturated solution of sodium chloride. The organic layer was dried over potassium carbonate, filtered, and the filtrate concentrated under reduced pressure to give 0.89 g of 4-(1-pyrrolyl)-2-indanyl acetate.

후처리

  1. temperatureunder reflux for 3 hours
  2. customThe organic layer was removed
  3. extractionthe aqueous layer extracted with two portions of 30 mL each of chloroform
  4. washThe combined organic phases were washed with two portions of 30 mL each of an aqueous saturated solution of sodium chloride
  5. dry with materialThe organic layer was dried over potassium carbonate
  6. filtrationfiltered
  7. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f48efcd4498e405eb6902c35614bd0c4
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04368205

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