(+-)-4-Hydroxymandelic acid → Sodium 4-hydroxyphenylglycolate

HRID 1164267

반응식

HRID 1164267 반응식
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]([OH:10])[C:7]([OH:9])=[O:8])=[CH:4][CH:3]=1.[OH-].[Na+:14]>C(C(C)=O)C(C)C>[OH:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]([OH:10])[C:7]([O-:9])=[O:8])=[CH:4][CH:3]=1.[Na+:14]

참가 물질

4

반응물 2

HCID 328(+-)-4-Hydroxymandelic acidHCID 14798Sodium Hydroxide

생성물 1

HCID 23663713Sodium 4-hydroxyphenylglycolate

시약·촉매·용매 1

HCID 7909Methyl Isobutyl Ketone용매

반응 조건

온도
20 °C

실험 절차

The procedure of Example 1 was repeated except that the organic phase containing p-hydroxymandelic acid was treated with a molar equivalent of sodium hydroxide as a 50% w/w aqueous solution. The caustic solution was added over one hour during which time the methyl isobutyl ketone solution was maintained at about 20° C. with cooling. The precipitate of sodium p-hydroxymandelate monohydrate was filtered off and suctioned as dry as possible before drying under vacuum at 40° C.

후처리

  1. temperaturewith cooling
  2. filtrationThe precipitate of sodium p-hydroxymandelate monohydrate was filtered off
  3. customas dry as possible
  4. custombefore drying under vacuum at 40° C.

출처 및 근거

ORD 기록
ord-efc510c327f446478b2c1dfe275dffcd
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04368334

연결된 노트

불러오는 중…