Hydrochloric Acid → N-(2-PIPERIDIN-4-YL-ETHYL)-ACETAMIDE

HRID 1164504노트

반응식

HRID 1164504 반응식
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)(=[O:3])[CH3:2].Cl.[H][H]>C(O)C.[Pt]=O>[C:1]([NH:4][CH2:5][CH2:6][CH:7]1[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)(=[O:3])[CH3:2]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 255093N-(2-Pyridin-4-yl-ethyl)-acetamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 4712038N-(2-PIPERIDIN-4-YL-ETHYL)-ACETAMIDE수율 52.6%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

4-(2-Acetamidoethyl)pyridine (33 g.) in ethanol (250 ml.) was acidified to pH 4 with hydrochloric acid and hydrogenated at 60 p.s.i./60° C. over a platinum oxide catalyst for 18 hours, after which time the uptake of hydrogen was complete. The catalyst was then removed by filtration and the filtrate was treated with a solution of potassium hydroxide flakes in methanol (1.1 molar equivalents) and refiltered. The solvents were distilled off in vacuo, leaving a clear oil, which on standing gave 4-(2-acetamidoethyl)piperidine (18 g.) as a white solid, m.p. 60° C.

후처리

  1. customThe catalyst was then removed by filtration
  2. additionthe filtrate was treated with a solution of potassium hydroxide flakes in methanol (1.1 molar equivalents)
  3. distillationThe solvents were distilled off in vacuo
  4. customleaving a clear oil, which

출처 및 근거

ORD 기록
ord-0994c038048a4bcc94138d57bf444953
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04370328

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