Hydrochloric Acid → N-[2-(Piperidin-4-yl)ethyl]methanesulfonamide--hydrogen chloride (1/1)

HRID 1164506노트

반응식

HRID 1164506 반응식
[CH3:1][S:2]([NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(=[O:4])=[O:3].[ClH:14].[H][H]>C(O)C.[Pt]=O>[ClH:14].[CH3:1][S:2]([NH:5][CH2:6][CH2:7][CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)(=[O:3])=[O:4]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 2797875HCID 2797875, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 20511180N-[2-(Piperidin-4-yl)ethyl]methanesulfonamide--hydrogen chloride (1/1)

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매2회

실험 절차

4-(2-methanesulphonamidoethyl)pyridine (8.4 g.) in ethanol (85 ml.) was acidified to pH 2 with 2 N HCl and hydrogenated at room temperature and a pressure of 50 p.s.i. over a platinum oxide catalyst until hydrogen uptake ceased. The catalyst was then removed by filtration and the filtrate was taken to dryness in vacuo to give a white solid which was dissolved in the minimum volume of hot ethanol, filtered quickly, and left at room temperature overnight. The resultant white crystals were collected by filtration and dried to yield 4-(2-methanesulphonamidoethyl)piperidine hydrochloride (8.3 g.), m.p. 165°-167° C.

후처리

  1. customThe catalyst was then removed by filtration
  2. customto give a white solid which
  3. filtrationfiltered quickly
  4. filtrationThe resultant white crystals were collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-fd2fe8615190497599dec3d452df03cd
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04370328

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