Traboxopine → HCID 14555943, 화합물

HRID 1164786노트

반응식

HRID 1164786 반응식
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]2[O:6][CH2:7][O:8][C:9]3[CH:22]=[CH:21][CH:20]=[CH:19][C:10]=3[N:11]([CH2:12][CH:13]([CH3:18])[CH2:14][N:15]([CH3:17])[CH3:16])[C:4]=2[CH:3]=1.[C:25]([OH:34])(=[O:33])[C@@H:26]([C@H:28]([C:30]([OH:32])=[O:31])[OH:29])[OH:27]>O>[C:30]([C@@H:28]([C@H:26]([C:25]([OH:34])=[O:33])[OH:27])[OH:29])([OH:32])=[O:31].[Cl:1][C:2]1[CH:24]=[CH:23][C:5]2[O:6][CH2:7][O:8][C:9]3[CH:22]=[CH:21][CH:20]=[CH:19][C:10]=3[N:11]([CH2:12][CH:13]([CH3:18])[CH2:14][N:15]([CH3:17])[CH3:16])[C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 129812TraboxopineHCID 444305L-Tartaric acid

생성물 1

HCID 14555943HCID 14555943, 화합물수율 70%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

From the dichloromethane filtrate obtained in Example 3, section (A), the base is deliberated by the method of Example 1, section (B). To the residual syrup weighing 21.5 g, 9.3 g 0.063 moles of L(+)-tartaric acid are added in 85 CM3 of water. At first, a solution is obtained that is stirred for several hours. The (-)-base L(+)-tartrate precipitated is filtered, suspended in cold water, then filtered, suspended and filtered again. Thus, 17.5 g (70.0%) of (-)-2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxazocine L(+)-tartrate are obtained, m.p.: 109°-114° C.

후처리

  1. customAt first, a solution is obtained
  2. customThe (-)-base L(+)-tartrate precipitated
  3. filtrationis filtered
  4. filtrationfiltered
  5. filtrationfiltered again

출처 및 근거

ORD 기록
ord-fce6a8337c934c9db4592a39aa34f74f
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04906622

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