Sodium Hydroxide → HCID 13560490, 화합물

HRID 1164841노트

반응식

HRID 1164841 반응식
C([O:3][C:4]([CH2:6][CH:7]1[NH:12][C:11]2[CH:13]=[C:14]([Cl:21])[C:15]([S:17](=[O:20])(=[O:19])[NH2:18])=[CH:16][C:10]=2[S:9](=[O:23])(=[O:22])[NH:8]1)=[O:5])C.[OH-].[Na+]>C(O)C>[C:4]([CH2:6][CH:7]1[NH:12][C:11]2[CH:13]=[C:14]([Cl:21])[C:15]([S:17](=[O:20])(=[O:19])[NH2:18])=[CH:16][C:10]=2[S:9](=[O:22])(=[O:23])[NH:8]1)([OH:5])=[O:3]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 136879873-Ethoxycarbonylmethyl-6-chloro-7-sulfamoyl-3, 4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide

생성물 1

HCID 13560490HCID 13560490, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Combine 3-ethoxycarbonylmethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide (7.7 g) with ethanol (EtOH) (250 ml) and 1N sodium hydroxide (NaOH) (70 ml) for 4 hours. Concentrate to 50 ml, add 1N hydrochloric acid (HCl) (70 ml), and extract with ethyl acetate (EtOAc). Dry the EtOAc extract over anhydrous magnesium sulfate and concentrate to obtain 3-carboxymethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide.

후처리

  1. concentrationConcentrate to 50 ml
  2. additionadd 1N hydrochloric acid (HCl) (70 ml)
  3. extractionextract with ethyl acetate (EtOAc)
  4. dry with materialDry the EtOAc
  5. extractionextract over anhydrous magnesium sulfate
  6. concentrationconcentrate

출처 및 근거

ORD 기록
ord-cd9e4b88f88948c0bd1f5336b7d8ceff
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04906635

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