Hydrochloric Acid → 8-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)-3-quinolinecarboxylic acid

HRID 1165366노트

반응식

HRID 1165366 반응식
Cl[C:2]1[C:11]([C:12]#[N:13])=[C:10]2[C:5]([C:6](=[O:20])[C:7]([C:17]([OH:19])=[O:18])=[CH:8][N:9]2[CH:14]2[CH2:16][CH2:15]2)=[CH:4][C:3]=1[F:21].[NH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.Cl>O1CCOCC1>[C:12]([C:11]1[C:2]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[C:3]([F:21])[CH:4]=[C:5]2[C:10]=1[N:9]([CH:14]1[CH2:16][CH2:15]1)[CH:8]=[C:7]([C:17]([OH:19])=[O:18])[C:6]2=[O:20])#[N:13]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4837PiperazineHCID 153471917-Chloro-8-cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

생성물 1

HCID 197766128-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)-3-quinolinecarboxylic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

0.5 g of the product from Example 1 and 0.42 g of piperazine are boiled in 8 ml of dioxane for 3 hours. The mixture is then concentrated in vacuo and 8 ml of water are added to the residue. The solution formed is rendered neutral with HCl and the solid which has precipitated out isolated, washed and dried.

후처리

  1. concentrationThe mixture is then concentrated in vacuo and 8 ml of water
  2. additionare added to the residue
  3. customThe solution formed
  4. customthe solid which has precipitated out
  5. customisolated
  6. washwashed
  7. customdried

출처 및 근거

ORD 기록
ord-9039e2d03ffd425f80d6c46641153fa2
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04908366

반응 노트

불러오는 중…