1-Methylpiperazine → 8-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

HRID 1165367노트

반응식

HRID 1165367 반응식
Cl[C:2]1[C:11]([C:12]#[N:13])=[C:10]2[C:5]([C:6](=[O:20])[C:7]([C:17]([OH:19])=[O:18])=[CH:8][N:9]2[CH:14]2[CH2:16][CH2:15]2)=[CH:4][C:3]=1[F:21].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>O1CCOCC1>[C:12]([C:11]1[C:2]([N:26]2[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]2)=[C:3]([F:21])[CH:4]=[C:5]2[C:10]=1[N:9]([CH:14]1[CH2:16][CH2:15]1)[CH:8]=[C:7]([C:17]([OH:19])=[O:18])[C:6]2=[O:20])#[N:13]

참가 물질

4

반응물 2

HCID 531671-MethylpiperazineHCID 153471917-Chloro-8-cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

생성물 1

HCID 197766178-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

0.5 g of the product from Example 1 and 0.48 g of N-methylpiperazine are boiled in 8 ml of dioxane for 3 hours. The mixture is then concentrated in vacuo, water is added to the residue and the solution formed is rendered neutral. The solid which has precipitated out is isolated, washed and dried.

후처리

  1. concentrationThe mixture is then concentrated in vacuo, water
  2. additionis added to the residue
  3. customthe solution formed
  4. customThe solid which has precipitated out
  5. customis isolated
  6. washwashed
  7. customdried

출처 및 근거

ORD 기록
ord-893b1073290041d09cacac1c59f47f4e
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04908366

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