Sodium Hydroxide → 3-H-epoxybenzazepin

반응식

C(O)(=O)C(O)=O.[O:7]1[CH:12]2[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH:8]1[CH2:9][NH:10][CH2:11]2.[OH-].[Na+]>>[N:10]1[C:9]2[CH:8]=[CH:14][CH:15]=[CH:16][C:17]=2[CH:18]=[CH:13][CH:12]2[O:7][C:11]=12

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 142087342,3,4,5-Tetrahydro-1H-1,5-epoxybenzo[d]azepine oxalate

생성물 1

HCID 867423053-H-epoxybenzazepin수율 103.8%

실험 절차

The product prepared in Example 19 (3.85 g, 0.15M) was made basic with NaOH, partitioned between H2O and CH2Cl2, and the organic layer dried (Na2SO4) and evaporated to give the 3-H-epoxybenzazepin (2.50 g, 0.015M). This compound was treated with propionic anhydride (10 ml) and allowed to stir for two hours. Excess propionic anhydride was removed in vacuo to give 3-propoxy-epoxybenzazepin as a white solid (3.3 g, 98% yield).

후처리

custompartitioned between H2O and CH2Cl2
dry with materialthe organic layer dried (Na2SO4)
customevaporated

출처 및 근거

ORD 기록: ord-766f6168eb3642358a1e3f9099485473
출처 데이터셋: uspto-grants-1990_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04910198

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