Dimethyl Sulfate → ethyl 3-methyl-3H-naphth[1,2-g]indol-2-carboxylate

HRID 1165663노트

반응식

HRID 1165663 반응식
S(OC)(O[CH3:5])(=O)=O.[CH:8]1[C:16]2[CH:15]=[CH:14][C:13]3[C:17]4[C:22]([CH:23]=[CH:24][C:12]=3[C:11]=2[NH:10][C:9]=1[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:21][CH:20]=[CH:19][CH:18]=4>C(Cl)Cl.CCCCCC>[CH3:5][N:10]1[C:11]2[C:12]3[CH:24]=[CH:23][C:22]4[C:17]([C:13]=3[CH:14]=[CH:15][C:16]=2[CH:8]=[C:9]1[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:18][CH:19]=[CH:20][CH:21]=4

참가 물질

4

반응물 2

HCID 6497Dimethyl SulfateHCID 20065898ethyl 3H-naphth[1,2-g]indole-2-carboxylate

생성물 1

HCID 20065897ethyl 3-methyl-3H-naphth[1,2-g]indol-2-carboxylate수율 74.5%

시약·촉매·용매 1

HCID 21226440Methylenechloride Hexane용매

실험 절차

Using the procedure outlined in Example 34A except that dimethyl sulfate was used as the alkylating agent, ethyl 3H-naphth[1,2-g]indole-2-carboxylate (H. G. Pars Pharmaceutical Laboratories, Inc.) gave a 74.5% yield of ethyl 3-methyl-3H-naphth[1,2-g]indol-2-carboxylate, mp 136°-138°, (CH2Cl2 /hexane), (C,H,N).

출처 및 근거

ORD 기록
ord-44b4821c008a486cbd4ead9ff45eb067
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04910218

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