Dimethyl Sulfate → Ethyl 3-methyl-3H-naphtho[2,3-e]indole-2-carboxylate

HRID 1165664노트

반응식

HRID 1165664 반응식
S(OC)(O[CH3:5])(=O)=O.[CH:8]1[C:16]2[C:15]3[CH:17]=[C:18]4[C:23](=[CH:24][C:14]=3[CH:13]=[CH:12][C:11]=2[NH:10][C:9]=1[C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH:22]=[CH:21][CH:20]=[CH:19]4>CCOC(C)=O.CCCCCC>[CH3:5][N:10]1[C:11]2[CH:12]=[CH:13][C:14]3[CH:24]=[C:23]4[C:18](=[CH:17][C:15]=3[C:16]=2[CH:8]=[C:9]1[C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH:19]=[CH:20][CH:21]=[CH:22]4

참가 물질

4

반응물 2

HCID 6497Dimethyl SulfateHCID 20065895HCID 20065895, 화합물

생성물 1

HCID 20065894Ethyl 3-methyl-3H-naphtho[2,3-e]indole-2-carboxylate수율 97%

시약·촉매·용매 1

HCID 21226206Ethyl acetate hexane용매

실험 절차

Using the procedure described in Example 34A except that dimethyl sulfate was used as the alkylating agent, ethyl 3H-naphth[2,3-e]indole-2-carboxylate (H. G. Pars Pharmaceutical Laboratories, Inc.) gave a 97% yield of ethyl 3-methyl-3H-naphth[2,3-e]indole-2-carboxylate, mp 141°-144°, (EtOAc/hexane), (C,H,N).

출처 및 근거

ORD 기록
ord-3d06a807322349ebbd5ddd3f097698c7
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04910218

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