Dimethylformamide → 6-Chloro-1,3-diethyl-5-formyluracil

HRID 1165776노트

반응식

HRID 1165776 반응식
[CH2:1]([N:3]1[C:10](=[O:11])[CH2:9][C:7](=O)[N:6]([CH2:12][CH3:13])[C:4]1=[O:5])[CH3:2].CN(C)[CH:16]=[O:17].P(Cl)(Cl)([Cl:21])=O>>[Cl:21][C:7]1[N:6]([CH2:12][CH3:13])[C:4](=[O:5])[N:3]([CH2:1][CH3:2])[C:10](=[O:11])[C:9]=1[CH:16]=[O:17]

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 1228891,3-Diethylbarbituric acid

생성물 1

HCID 126779796-Chloro-1,3-diethyl-5-formyluracil

실험 절차

To a solution of 1,3-diethylbarbituric acid (61 g) in phosphorus oxychloride (224 ml) was added dimethylformamide (35 ml) with stirring at room temperature and then the reaction solution was refluxed for 3.5 hr. The solution was concentrated to dryness to give an oil. The oil was poured into ice-water to give crystals, 6-chloro-1,3-diethyl-5-formyluracil (64 g), m.p. 88°-89° C.

후처리

  1. temperaturethe reaction solution was refluxed for 3.5 hr
  2. concentrationThe solution was concentrated to dryness
  3. customto give an oil

출처 및 근거

ORD 기록
ord-e203105119c94901bb1ddb08b97df94c
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04912104

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