Phosphorus oxychloride → 2-(4-Chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline

HRID 1166147노트

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](O)[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:27])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([Cl:27])[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 178486767HCID 178486767, 화합물

생성물 1

HCID 117834712-(4-Chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline

실험 절차

18.2 g of 2-(4-chlorophenyl)-hydroxy-6,7,8-trimethoxyquinazoline were heated at 100° C. for 3 h in 120 ml of phosphorus oxychloride. The excess phosphorus oxychloride was distilled off and the oily residue was stirred with ice water. The solid was filtered off with suction and dried under reduced pressure. Yield: 15.0 g. M.p.: 159° C.

후처리

distillationThe excess phosphorus oxychloride was distilled off
filtrationThe solid was filtered off with suction
customdried under reduced pressure

출처 및 근거

ORD 기록: ord-f7ab9f2dd19e434aa7fb150c69033950
출처 데이터셋: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06613772B1

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