Hydrochloric Acid → 3-[1,4']Bipiperidinyl-1'-ylmethyl-2-phenyl-quinoline-4-carboxylic acid dihydrochloride

HRID 1166274노트

반응식

HRID 1166274 반응식
C[O:2][C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6]=1[CH2:21][N:22]1[CH2:27][CH2:26][CH:25]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH2:24][CH2:23]1)=[O:4].[ClH:34]>>[ClH:34].[ClH:34].[N:28]1([CH:25]2[CH2:26][CH2:27][N:22]([CH2:21][C:6]3[C:7]([C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=4)=[N:8][C:9]4[C:14]([C:5]=3[C:3]([OH:4])=[O:2])=[CH:13][CH:12]=[CH:11][CH:10]=4)[CH2:23][CH2:24]2)[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 108131493-[1,4']Bipiperidinyl-1'-ylmethyl-2-phenyl-quinoline-4-carboxylic Acid Methyl Ester

생성물 1

HCID 695475013-[1,4']Bipiperidinyl-1'-ylmethyl-2-phenyl-quinoline-4-carboxylic acid dihydrochloride

실험 절차

3.5 g (7.9 mmol) of 3-[1,4′]bipiperidinyl-1′-ylmethyl-2-phenyl-quinoline-4-carboxylic acid methyl ester (compound of Description 5) and 50 ml of 6N HCl are refluxed for 1.5 h and then concentrated to dryness. The residue was triturated in acetone. This process was re-applied twice to the solid thus obtained affording, after drying in vacuo, 4.5 g of the title compound as a crude dihydrochloride used without further purification in the next step.

후처리

  1. concentrationconcentrated to dryness
  2. customThe residue was triturated in acetone
  3. customthus obtained
  4. customaffording
  5. dry with materialafter drying in vacuo, 4.5 g of the title compound as a crude dihydrochloride
  6. customused without further purification in the next step

출처 및 근거

ORD 기록
ord-5b5dc832b4634dd88f002c9548a9ded1
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06613770B1

반응 노트

불러오는 중…