Dimethyl Sulfoxide → 1-bromo-N-[(1-formyl)propyl]-cyclopropane-1-carboxamide

HRID 1166626노트

반응식

HRID 1166626 반응식
C(Cl)(=O)[C:2](Cl)=[O:3].CS(C)=O.[Br:11][C:12]1([C:15]([NH:17][CH2:18][CH2:19][CH2:20]CO)=[O:16])[CH2:14][CH2:13]1.[Cl-].[Na+]>C(Cl)Cl.C(N(CC)CC)C>[Br:11][C:12]1([C:15]([NH:17][CH:18]([CH:2]=[O:3])[CH2:19][CH3:20])=[O:16])[CH2:13][CH2:14]1

참가 물질

7

반응물 4

HCID 679Dimethyl SulfoxideHCID 5234Sodium ChlorideHCID 65578Oxalyl chlorideHCID 694261281-bromo-N-[(1-hydroxymethyl)propyl]-cyclopropane-1-carboxamide

생성물 1

HCID 180008601-bromo-N-[(1-formyl)propyl]-cyclopropane-1-carboxamide

시약·촉매·용매 2

HCID 6344Dichloromethane용매3회HCID 8471Triethylamine용매

실험 절차

2.23 ml of oxalyl chloride in 102 ml of methylene chloride is mixed drop by drop at −78° C. under nitrogen with 3.6 ml of dimethylsulfoxide in 41 ml of methylene chloride. Then, 5.43 g of amide alcohol 78 in 41 ml of methylene chloride and, after 15 minutes, 14.3 ml of triethylamine are added in drops at −78° C. After another 30 minutes, sodium chloride solution is added, extracted with methylene chloride, dried on sodium sulfate and concentrated by evaporation. The residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 3.4 g of 1-bromo-N-[(1-formyl)propyl]-cyclopropane-1-carboxamide 79 is obtained as a yellow oil, which is converted into title compound 80 analogously to the reaction of amide 76.

후처리

  1. extractionextracted with methylene chloride
  2. customdried on sodium sulfate
  3. concentrationconcentrated by evaporation
  4. customThe residue is chromatographed on silica gel with ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-e9dfb15bcbba4a0d9356f6789b10ed72
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06613920B1

반응 노트

불러오는 중…