Lithium hydroxide, monohydrate → HCID 69655737, 화합물

HRID 11667

반응식

HRID 11667 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH2:22][C:23]([N:25]2[CH2:30][C@H:29]([CH3:31])[N:28]([CH2:32][C:33]3[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=3)[CH2:27][C@H:26]2[CH3:40])=[O:24])=[C:6]([S:8]([NH:11][C:12](=[O:20])[C:13]([O:16]C(=O)C)([CH3:15])[CH3:14])(=[O:10])=[O:9])[CH:7]=1.O.[OH-].[Li+]>O1CCCC1.CO.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH2:22][C:23]([N:25]2[CH2:30][C@H:29]([CH3:31])[N:28]([CH2:32][C:33]3[CH:34]=[CH:35][C:36]([F:39])=[CH:37][CH:38]=3)[CH2:27][C@H:26]2[CH3:40])=[O:24])=[C:6]([S:8]([NH:11][C:12](=[O:20])[C:13]([OH:16])([CH3:14])[CH3:15])(=[O:10])=[O:9])[CH:7]=1

참가 물질

6

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 69655351Acetic Acid 2-(5-Chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzenesulfonylamino)-1,1-dimethyl-2-oxo-ethyl Ester

생성물 1

HCID 69655737HCID 69655737, 화합물수율 89.1%

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of acetic acid 2-(5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzenesulfonylamino)-1,1-dimethyl-2-oxo-ethyl ester (0.14 g, 0.21 mmol) in tetrahydrofuran (2 mL), methanol (0.2 mL) and water (0.4 mL) was added lithium hydroxide monohydrate (0.020 g, 0.48 mmol). The resulting reaction mixture was stirred at ambient temperature overnight. Chromatography on silica gel of the reaction mixture provided the title compound (0.104 g, LRMS: 556.3).

후처리

  1. customThe resulting reaction mixture

출처 및 근거

ORD 기록
ord-8e14bb657fa8415fa72446efe618afdc
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098212B2

연결된 노트

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