Hydrochloric Acid → 1-Formyl-4-(3-hydroxypropyl)naphthalene

HRID 1166746노트

반응식

HRID 1166746 반응식
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([CH:15]2OCC[O:16]2)=[CH:7][CH:6]=1.Cl>C1COCC1.C(OCC)C>[CH:15]([C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([CH2:4][CH2:3][CH2:2][OH:1])=[CH:6][CH:7]=1)=[O:16]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 538626532-[4-(3-Hydroxypropyl)naphthyl]dioxolane

생성물 1

HCID 229990881-Formyl-4-(3-hydroxypropyl)naphthalene수율 72%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-[4-(3-hydroxypropyl)naphthyl]dioxolane (67 mg, 0.26 mmol) in anhydrous THF (5 mL) was added 1 N hydrochloric acid (1 mL). The mixture was stirred at room temperature for 48 hr, diluted with ethyl ether (20 mL), washed with satd. NaHCO3 solution (2×10 mL), dried (MgSO4), concentrated and coevaporated with CHCl3 (3×10 mL) to yield 40 mg (72%) of a colorless oil.

후처리

  1. washwashed with satd
  2. dry with materialNaHCO3 solution (2×10 mL), dried (MgSO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-75ee93236f24446fba7e33b0951922d5
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06613942B1

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