Boron tribromide → (5-Chloro-2-hydroxyphenyl)methanesulfonamide
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:13]C)=[C:6]([CH2:8][S:9]([NH2:12])(=[O:11])=[O:10])[CH:7]=1.B(Br)(Br)Br>ClC(Cl)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]([CH2:8][S:9]([NH2:12])(=[O:11])=[O:10])[CH:7]=1참가 물질
4
실험 절차
To a suspension of (5-chloro-2-methoxy-phenyl)-methanesulfonamide (0.03 g, 0.13 mmol) in dichloroethane (1.5 mL) was added boron tribromide solution (1M in dichloromethane, 0.26 mL, 0.26 mmol). The reaction was stirred for one hour at ambient temperature. The reaction was quenched with water, saturated with sodium chloride and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated to give the title compound (0.025 g).
후처리
- customThe reaction was quenched with water, saturated with sodium chloride
- extractionextracted with ethyl acetate
- dry with materialThe organic layer was dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-b4060db022494b248124cc4b060088c2
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07098212B2
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