Methyl 2-methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate → 2-Methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylic acid

HRID 1167108

반응식

HRID 1167108 반응식
[CH3:1][C:2]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)([CH2:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]([C:20]2[C:21]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=3)=[CH:22][CH:23]=[CH:24][CH:25]=2)=[O:19])[CH2:13][CH2:12]1)[CH2:3][C:4]([O:6]C)=[O:5]>Cl>[CH3:1][C:2]([C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)([CH2:8][CH2:9][CH2:10][N:11]1[CH2:12][CH2:13][CH:14]([NH:17][C:18]([C:20]2[C:21]([C:26]3[CH:27]=[CH:28][C:29]([C:32]([F:33])([F:34])[F:35])=[CH:30][CH:31]=3)=[CH:22][CH:23]=[CH:24][CH:25]=2)=[O:19])[CH2:15][CH2:16]1)[CH2:3][C:4]([OH:6])=[O:5]

참가 물질

3

반응물 1

HCID 22995529Methyl 2-methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate

생성물 1

HCID 229956572-Methyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A suspension of 1.5 g (0.0027 mol) of methyl 2-methyl-2-phenyl-5-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate in 60 ml of 6N hydrochloric acid is refluxed for 25 hours. After cooling the precipitate is filtered off and washed with water and ethyl acetate.

후처리

  1. temperatureis refluxed for 25 hours
  2. temperatureAfter cooling the precipitate
  3. filtrationis filtered off
  4. washwashed with water and ethyl acetate

출처 및 근거

ORD 기록
ord-de572782bbc54cb987698d8e06304563
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06617325B1

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