Hydrochloric Acid → Ethyl 2-isopropoxy-4-methoxybenzimidate hydrochloride

HRID 1167304노트

반응식

HRID 1167304 반응식
[ClH:1].[CH:2]([O:5][C:6]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:7]=1[C:8]#[N:9])([CH3:4])[CH3:3].[CH2:16]([OH:18])[CH3:17]>>[ClH:1].[CH:2]([O:5][C:6]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:7]=1[C:8](=[NH:9])[O:18][CH2:16][CH3:17])([CH3:4])[CH3:3]

참가 물질

4

반응물 3

HCID 313Hydrochloric Acid2회HCID 702EthanolHCID 227210812-Isopropoxy-4-methoxybenzonitrile

생성물 1

HCID 21896893Ethyl 2-isopropoxy-4-methoxybenzimidate hydrochloride수율 99%

반응 조건

온도
-10 °C

실험 절차

Hydrogen chloride gas was passed through a solution of 2-isopropoxy-4-methoxy-benzonitrile (11.5 g, 60.14 mmol) in anhydrous ethanol (250 mL) cooled to −10° C. After 45 min, hydrogen chloride gas was stopped and the reaction mixture was stirred at room temperature in a closed reaction vessel for 2 weeks. The reaction vessel was cooled to 0° C. before the stopper was removed. Argon gas was passed through the solution to remove excess hydrogen chloride gas. The solvent was evaporated and the residue was triturated in diethyl ether (100 mL) to afford ethyl 2-isopropoxy-4-methoxy-benzimidate hydrochloride (16.3 g, 99%). It was used without further purification.

후처리

  1. temperatureThe reaction vessel was cooled to 0° C. before the stopper
  2. customwas removed
  3. customto remove excess hydrogen chloride gas
  4. customThe solvent was evaporated
  5. customthe residue was triturated in diethyl ether (100 mL)

출처 및 근거

ORD 기록
ord-569752e827a34fd0a523bb50db91fa0e
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06617346B1

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