Hydrochloric Acid → Ethyl 2-(2-dimethylamino-ethoxy)-4-methoxy-benzimidate hydrochloride

HRID 1167313노트

반응식

HRID 1167313 반응식
[ClH:1].[CH3:2][N:3]([CH3:17])[CH2:4][CH2:5][O:6][C:7]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:8]=1[C:9]#[N:10].[CH2:18]([OH:20])[CH3:19]>>[ClH:1].[CH3:2][N:3]([CH3:17])[CH2:4][CH2:5][O:6][C:7]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:8]=1[C:9](=[NH:10])[O:20][CH2:18][CH3:19]

참가 물질

4

반응물 3

HCID 313Hydrochloric Acid2회HCID 702EthanolHCID 229961862-(2-Dimethylamino-ethoxy)-4-methoxy-benzonitrile

생성물 1

HCID 22996253Ethyl 2-(2-dimethylamino-ethoxy)-4-methoxy-benzimidate hydrochloride수율 96%

실험 절차

Hydrogen chloride gas was passed through a solution of 2-(2-dimethylamino-ethoxy)-4-methoxy-benzonitrile (200 mg, 0.908 mmol) in anhydrous ethanol (10 mL) at 0° C. After 45 min, hydrogen chloride gas was stopped and the reaction vessel was sealed with a septum. After stirring at room temperature for 3 d, the reaction vessel was cooled to 0° C. and the septum was removed. The solvent was removed in vacuo to afford ethyl 2-(2-dimethylamino-ethoxy)-4-methoxy-benzimidate hydrochloride as a pale-yellow foam (310 mg, 96%). It was used without further purification.

후처리

  1. customthe reaction vessel was sealed with a septum
  2. temperaturethe reaction vessel was cooled to 0° C.
  3. customthe septum was removed
  4. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-8bc3f7b5c9f24227b5860e0d847c807e
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06617346B1

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