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2-(5-Chloro-3-nitro-pyridin-2-yloxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone → 2-(3-Amino-5-chloro-pyridin-2-yloxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

HRID 11674
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HRID 11674 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N+:27]([O-])=O)[C:5]([O:8][CH2:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[CH2:14][C@H:13]2[CH3:26])=[O:11])=[N:6][CH:7]=1.[H][H]>C(O)C.[Pt](=O)=O>[NH2:27][C:4]1[C:5]([O:8][CH2:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[CH2:14][C@H:13]2[CH3:26])=[O:11])=[N:6][CH:7]=[C:2]([Cl:1])[CH:3]=1
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참가 물질

5

반응물 2

HCID 696557252-(5-Chloro-3-nitro-pyridin-2-yloxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanoneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 696554982-(3-Amino-5-chloro-pyridin-2-yloxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone수율 86.3%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702
Ethanol
용매

실험 절차

To a solution of 2-(5-chloro-3-nitro-pyridin-2-yloxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone (0.96 g, 2.3 mmol) in ethanol (25 mL) was added platinum dioxide on carbon (0.90 mg, 5% on carbon). The reaction was subject to 35 psi hydrogen gas for 20 minutes. The reaction was filtered through celite, concentrated in vacuo and chromatographed on silica gel to give the title compound (0.78 g).

후처리

  1. filtrationThe reaction was filtered through celite
  2. concentrationconcentrated in vacuo
  3. customchromatographed on silica gel

출처 및 근거

ORD 기록
ord-9f991950fe5e4b9e8a888fb8464d34a7
출처 데이터셋
uspto-grants-2006_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07098212B2

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