Tetrahydrofuran → HCID 59093773, 화합물

HRID 1167605노트

반응식

HRID 1167605 반응식
[BH4-].[Na+].C1COCC1.[CH:8]([C:10]1[Se:11][C:12]([C:15]2[Se:16][C:17]([C:20]3[Se:21][C:22]([CH:25]=[O:26])=[CH:23][CH:24]=3)=[CH:18][CH:19]=2)=[CH:13][CH:14]=1)=[O:9]>C(OCC)(=O)C>[OH:26][CH2:25][C:22]1[Se:21][C:20]([C:17]2[Se:16][C:15]([C:12]3[Se:11][C:10]([CH2:8][OH:9])=[CH:14][CH:13]=3)=[CH:19][CH:18]=2)=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 59093769HCID 59093769, 화합물

생성물 1

HCID 59093773HCID 59093773, 화합물수율 98%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

NaBH4 (10 mg) was added to a THF solution (2 mL) containing 2,5″-diformyl-5,2′:5′,2″-terselenophene (15 mg) and stirred at room temperature for 5 h. The reaction solution was diluted with ethyl acetate (50 mL), washed with 2N HCl (5 mL), and washed with H2O (3×100 mL). The organic layer was separated, dried over MgSO4, filtered, and the solvent was removed under vacuum. The residue was chromatographed over silica gel using (1:1) hexanes/ethyl acetate to afford 2,5″-dihydroxymethyl-5,2′:5′,2″-terselenophene in 98% yield.

후처리

  1. washwashed with 2N HCl (5 mL)
  2. washwashed with H2O (3×100 mL)
  3. customThe organic layer was separated
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customthe solvent was removed under vacuum
  7. customThe residue was chromatographed over silica gel using (1:1) hexanes/ethyl acetate

출처 및 근거

ORD 기록
ord-88c8d42dea154ee794f0f3030e6fced4
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06620804B2

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