Hydrochloric Acid → [4-(4-Methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol-2-yl]amine hydrochloride

HRID 1167650

반응식

HRID 1167650 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([NH2:20])[S:12][C:13]=2[C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[CH:5][CH:4]=1.[ClH:21]>CO>[ClH:21].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]=[C:11]([NH2:20])[S:12][C:13]=2[C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 30248942-Thiazolamine, 4-(4-methoxyphenyl)-5-(3-pyridinyl)-

생성물 1

HCID 13518884[4-(4-Methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol-2-yl]amine hydrochloride수율 80%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

[4-(4-Methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol-2-yl]amine (200 mg) was dissolved in 1% methanol solution of hydrogen chloride (3.2 mL), and the solvent was evaporated. The crude crystalline was recrystallized from methanol-ethyl acetate to give the title compound (180 mg, yield 80%).

후처리

  1. customthe solvent was evaporated
  2. customThe crude crystalline was recrystallized from methanol-ethyl acetate

출처 및 근거

ORD 기록
ord-a3a863d09d644c3eaf32f139827f41ad
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06620825B1

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