Chlorosulfonic acid → 7-Bromo-dibenzofuran-2-sulfonyl Chloride

HRID 1167731노트

반응식

HRID 1167731 반응식
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Br:6][C:7]1[CH:8]=[CH:9][C:10]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[O:12][C:11]=2[CH:19]=1.P(Cl)(Cl)(Cl)(Cl)Cl>C(Cl)(Cl)Cl>[Br:6][C:7]1[CH:8]=[CH:9][C:10]2[C:14]3[CH:15]=[C:16]([S:2]([Cl:1])(=[O:5])=[O:3])[CH:17]=[CH:18][C:13]=3[O:12][C:11]=2[CH:19]=1

참가 물질

5

반응물 3

HCID 24638Chlorosulfonic acidHCID 24819Phosphorus pentachlorideHCID 2968613-Bromodibenzofuran

생성물 1

HCID 223945507-Bromo-dibenzofuran-2-sulfonyl Chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
0 °C

실험 절차

Chlorosulfonic acid (3.75 mL, 56 mmoles) was added dropwise to a solution of 3-bromo-dibenzofuran (9.21 g, 37.3 mmoles) in 150 mL of chloroform at room temperature. The reaction was stirred for 5 hours, cooled to 0° C., filtered, and washed the solid with cold dichloromethane. This solid (6.12 g, 18.7 mmoles) was mixed with phosphorous pentachloride (12.9 g, 61.7 mmoles) and the mixture was heated to 110° C. for 4 hours. The mixture was cooled to room temperature and quenched with ice water. Filtered the resulting suspension to give the title compound as a white solid.

후처리

  1. filtrationfiltered
  2. washwashed the solid with cold dichloromethane
  3. temperaturethe mixture was heated to 110° C. for 4 hours
  4. temperatureThe mixture was cooled to room temperature
  5. customquenched with ice water
  6. filtrationFiltered the resulting suspension

출처 및 근거

ORD 기록
ord-55156a64094e4f0aa4eda3e83edeacfc
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06620835B2

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