Camphor → Borneol
반응식
[2H-].[Al+3].[Li+].[2H-].[2H-].[2H-].[C:7]12([CH3:17])[C:14]([CH3:16])([CH3:15])[CH:11]([CH2:12][CH2:13]1)[CH2:10][C:8]2=[O:9].[H-]>CCOCC>[CH3:15][C:14]1([CH3:16])[C:7]2([CH3:17])[CH:8]([OH:9])[CH2:10][CH:11]1[CH2:12][CH2:13]2참가 물질
5
실험 절차
To a slurry of lithium aluminum deuteride (LiAlD4) (0.012 g) in anhydrous ether (1 mL) was added, with stirring, camphor (0.1 g) in ether (2 mL), followed by heating at reflux for 3 hours. After cooling to room temperature, the excess hydride was decomposed by addition of moist ether, then the organic layer was washed with brine, dried (Na2CO4) and evaporated to give a quantitative yield of deuteriated isoborneol (0.1 g). 2H NMR (hexanes): δ 3.75. See B. Belleau, J. Am. Chem. Soc., 82, p. 5751 (1960).
후처리
- temperatureby heating
- temperatureat reflux for 3 hours
- washthe organic layer was washed with brine
- dry with materialdried (Na2CO4)
- customevaporated
출처 및 근거
- ORD 기록
- ord-bf1a3af668ac4abbb310bc752e1b641b
- 출처 데이터셋
- uspto-grants-2003_09
- 특허 번호
- US06620972B2
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