홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Hydroxide → 3-Butyl-1-methyl-4-(1-methylindol-3-yl)pyrrole-2,5-dione

HRID 1168659
노트
인쇄 미리보기

반응식

HRID 1168659 반응식
CC(C)C(N)=O.[OH-].[Na+].CN1C2C(=CC=CC=2)C(C2C(=O)N(C)C(=O)C=2Cl)=C1.[CH3:28][N:29]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:31]([C:38]2[C:43](=[O:44])[N:42]([CH3:45])[C:40](=[O:41])[C:39]=2[C:46]2C=C[CH:49]=[CH:48][CH:47]=2)=[CH:30]1.Cl.O>O>[CH3:49][CH2:48][CH2:47][CH2:46][C:39]1[C:40](=[O:41])[N:42]([CH3:45])[C:43](=[O:44])[C:38]=1[C:31]1[C:32]2[C:37](=[CH:36][CH:35]=[CH:34][CH:33]=2)[N:29]([CH3:28])[CH:30]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 5

HCID 14798Sodium HydroxideHCID 68424Isobutyramide2회HCID 178316153-Chloro-1-methyl-4-(1-methylindol-3-yl)pyrrole-2,5-dioneHCID 178436842-(1-methyl-1H-indol-3-yl)-3-phenyl-N-methylmaleimideHCID 21885828Hydrate;hydrochloride

생성물 1

HCID 1022626083-Butyl-1-methyl-4-(1-methylindol-3-yl)pyrrole-2,5-dione
수율 85.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Into dimethylacetoamide (30 ml) was dispersed sodium hydroxide (content: 60%, 0.88 g, 22 mmol). To this were added IM-3 obtained in Example 1-2 (1.77 g, 10 mmol)/dimethylacetoamide (5 ml). This mixture was stirred for 10 minutes, then, to this was added IM-5 (4.5 g, 11 mmol) obtained as described above, and this mixture was stirred for three hours. To this was added water (10 ml), and this mixture was acidified with 1N water hydrochloride, and the reaction solution was concentrated. The concentrated mixture was refined with silica gel column chromatography to obtain 2.8 g of IM-6.

후처리

  1. customobtained
  2. stirringwas stirred for three hours
  3. concentrationthe reaction solution was concentrated

출처 및 근거

ORD 기록
ord-9385340d53934a99add929f6a0125ba7
출처 데이터셋
uspto-grants-2003_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06627099B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트