Chloroform → 7,9-Dibromo-beta-carboline hydrochloride

HRID 1168719노트

반응식

HRID 1168719 반응식
[Br:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:11]=3[NH:12]2)=[CH:4][CH:3]=1.[Br:15]Br.C(Cl)(Cl)[Cl:18]>C1COCC1>[ClH:18].[Br:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:11]=3[N:12]2[Br:15])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6212ChloroformHCID 24408BromineHCID 145928Eudistomin O

생성물 1

HCID 221852417,9-Dibromo-beta-carboline hydrochloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of the product from example 1 (140 mg, 0.58 mmol) in THF (2 ml) was treated with bromine (0.50 ml). After 10 min at RT, the reaction was diluted with chloroform and the product was filtered. The filtered product was taken up in methanol and treated with 1M HCl in ether and concentrated. The residue was triturated with ether to provide 160 mg of 7,9-dibromo-β-carboline hydrochloride.

후처리

  1. filtrationthe product was filtered
  2. additiontreated with 1M HCl in ether
  3. concentrationconcentrated
  4. customThe residue was triturated with ether

출처 및 근거

ORD 기록
ord-52b42d2aed7643979ed7dd67d71e2d1c
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627637B2

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