2-Benzofurancarboxylic acid, 5-nitro-, ethyl ester → Ethyl 5-aminobenzofuran-2-carboxylate

HRID 1169

반응식

HRID 1169 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:9][C:8]=2[CH:17]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:9][C:8]=2[CH:17]=1

참가 물질

4

반응물 1

HCID 13829542-Benzofurancarboxylic acid, 5-nitro-, ethyl ester

생성물 1

HCID 9837138Ethyl 5-aminobenzofuran-2-carboxylate

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A solution of 2.3 g of ethyl 5-nitrobenzofuran-2-carboxylate in 60 ml of methanol is hydrogenated in the presence of Raney nickel. The catalyst is filtered off and the solution is concentrated. After customary working up, ethyl 5-aminobenzofuran-2-carboxylate, Rf 0.1 (dichloromethane/ethanol 9.5:0.5) obtained; hydrochloride m.p. 246°-248°.

후처리

  1. filtrationThe catalyst is filtered off
  2. concentrationthe solution is concentrated

출처 및 근거

ORD 기록
ord-fb1ddf8127a44d35bcac2a8bffbfe5d1
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723614

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