Sodium Hydroxide → N-[6-[3-[4-(diphenylmethoxy)piperidino]propylamino][1,2,4]triazolo[1,5-b]pyridazine-2-carbonyl]glycine

HRID 1169106노트

반응식

HRID 1169106 반응식
C([O:3][C:4](=[O:42])[CH2:5][NH:6][C:7]([C:9]1[N:17]=[C:16]2[N:11]([N:12]=[C:13]([NH:18][CH2:19][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][CH:25]([O:28][CH:29]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)[C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH2:24][CH2:23]3)[CH:14]=[CH:15]2)[N:10]=1)=[O:8])C.[OH-].[Na+]>C(O)C>[C:36]1([CH:29]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[O:28][CH:25]2[CH2:24][CH2:23][N:22]([CH2:21][CH2:20][CH2:19][NH:18][C:13]3[CH:14]=[CH:15][C:16]4[N:11]([N:10]=[C:9]([C:7]([NH:6][CH2:5][C:4]([OH:42])=[O:3])=[O:8])[N:17]=4)[N:12]=3)[CH2:27][CH2:26]2)[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22989377N-[6-[3-[4-(diphenylmethoxy)piperidino]propylamino][1,2,4]triazolo[1,5-b]pyridazine-2-carbonyl]glycine ethyl ester

생성물 1

HCID 22989431N-[6-[3-[4-(diphenylmethoxy)piperidino]propylamino][1,2,4]triazolo[1,5-b]pyridazine-2-carbonyl]glycine수율 50.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

928 mg of N-[6-[3-[4-(diphenylmethoxy)piperidino]propylamino][1,2,4]triazolo[1,5-b]pyridazine-2-carbonyl]glycine ethyl ester was dissolved in 7 ml of ethanol; 2.2 ml of a 1 N aqueous solution of sodium hydroxide was added, followed by stirring at room temperature for 1.5 hours. The mixture was concentrated under reduced pressure. The residue was diluted with water; 1 N hydrochloric acid was added to bring the mixture to pH 4.5. The crystal obtained was collected by filtration, washed with water, acetone and ethyl acetate and dried to yield 443 mg of the title compound.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. additionThe residue was diluted with water
  3. addition1 N hydrochloric acid was added
  4. customThe crystal obtained
  5. filtrationwas collected by filtration
  6. washwashed with water, acetone and ethyl acetate
  7. customdried

출처 및 근거

ORD 기록
ord-3a39bd3fe2ce4137a7687896c58c368f
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627630B1

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