Sodium Hydroxide → HCID 11746720, 화합물
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:17])([CH3:16])[C:12]([O:14]C)=[O:13])[N:10]=2)[N:7]=1.[OH-].[Na+]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:17])([CH3:16])[C:12]([OH:14])=[O:13])[N:10]=2)[N:7]=1참가 물질
4
실험 절차
1.40 g of methyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionate was dissolved in 15 ml of tetrahydrofuran; 9 ml of a 1 N aqueous solution of sodium hydroxide was added, followed by stirring at room temperature for 3 hours. After the mixture was concentrated under reduced pressure. The residue was adjusted top H4 by the addition of 1N hydrochloric acid; the crystal precipitated was collected by filtration to yield 1.06 g of the title compound.
후처리
- concentrationAfter the mixture was concentrated under reduced pressure
- additionby the addition of 1N hydrochloric acid
- customthe crystal precipitated
- filtrationwas collected by filtration
출처 및 근거
- ORD 기록
- ord-85b1d20b86504078a24ddfa853caf36d
- 출처 데이터셋
- uspto-grants-2003_09
- 특허 번호
- US06627630B1
반응 노트
불러오는 중…