Hydrochloric Acid → 4-amino-1-[2-[N-methyl-N-(tetrahydropyran-4-yl)amino]ethyl]piperidine dihydrochloride

HRID 1169407노트

반응식

HRID 1169407 반응식
[CH3:1][N:2]([CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH:14]([NH:17]C(=O)OC(C)(C)C)[CH2:13][CH2:12]1)[CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.[ClH:25]>C(O)C>[ClH:25].[ClH:25].[NH2:17][CH:14]1[CH2:13][CH2:12][N:11]([CH2:10][CH2:9][N:2]([CH3:1])[CH:3]2[CH2:8][CH2:7][O:6][CH2:5][CH2:4]2)[CH2:16][CH2:15]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 70023872tert-butyl 1-[2-[N-methyl-N-(tetrahydropyran-4-yl)amino]ethyl]-4-piperidinylcarbamate

생성물 1

HCID 229899814-amino-1-[2-[N-methyl-N-(tetrahydropyran-4-yl)amino]ethyl]piperidine dihydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Into a solution of tert-butyl 1-[2-[N-methyl-N-(tetrahydropyran-4-yl)amino]ethyl]-4-piperidinylcarbamate (2.72 g) in ethanol (30 ml) was added concentrated hydrochloric acid (10 ml), and the resulting mixture was stirred for 7 hours. After the reaction mixture was concentrated under reduced pressure, ethanol and methanol are added to the residue, and the resulting mixture was concentrated further. The precipitate was collected by filtration and was washed with ethanol and methanol to obtain 4-amino-1-[2-[N-methyl-N-(tetrahydropyran-4-yl)amino]ethyl]piperidine dihydrochloride (1.65 g) as a light yellow powder.

후처리

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure, ethanol and methanol
  2. additionare added to the residue
  3. concentrationthe resulting mixture was concentrated further
  4. filtrationThe precipitate was collected by filtration
  5. washwas washed with ethanol and methanol

출처 및 근거

ORD 기록
ord-5a542f1c05824a9bb4f1fd32cd762dce
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627651B1

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