Methyl iodide → HCID 22990064, 화합물

HRID 1169435노트

반응식

HRID 1169435 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:28]=[CH:29][CH:30]=1)[C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:17][CH:16]=1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[I:32].[C:33](OCC)(=O)C>CN(C=O)C>[I-:32].[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:28]=[CH:29][CH:30]=1)[C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N+:22]2([CH3:33])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]2)=[CH:17][CH:16]=1)=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 29671333-(Phenylmethoxy)-N-[4-(1-piperidinylmethyl)phenyl]benzamide

생성물 1

HCID 22990064HCID 22990064, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 3-benzyloxy -4′-(piperidinomethyl)benzanilide (560 mg) dissolved in DMF (3 ml) was added methyl iodide (261 μl), and the resulting mixture was stirred at room temperature for 14 hours. Ethyl acetate (100 ml) was added to this reaction mixture, and the resulting precipitate was collected by filtration to obtain 1-[4-(3-benzyloxybenzoylamino)benzyl]-1-methylpiperidinium iodide (compound 87) (724 mg) as colorless crystals.

후처리

  1. filtrationthe resulting precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-cebaaf440f524928b6888f9b4a0003b1
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627651B1

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