Methanol → 3,4-Diethoxybenzyl alcohol

HRID 1169503

반응식

HRID 1169503 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH3:14])[CH:7]=[O:8])[CH3:2].CO.[BH4-].[Na+]>O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][CH3:14])[CH2:7][OH:8])[CH3:2]

참가 물질

5

반응물 3

HCID 887MethanolHCID 748473,4-DiethoxybenzaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 8540533,4-Diethoxybenzyl alcohol수율 98.4%

시약·촉매·용매 1

HCID 962Water용매

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온도
0 °C

실험 절차

To a mixture of 3,4-diethoxybenzaldehyde (6.68 g) and methanol (100 ml) was added sodium borohydride (1.30 g) at 0° C. The resulting mixture was stirred at 0° C. for 45 minutes. The reaction mixture was mixed with water and was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated solution of sodium chloride and was dried with anhydrous magnesium sulfate. The resulting organic layer was evaporated under reduced pressure to remove the solvent to obtain 3,4-diethoxybenzyl alcohol (6.64 g) as a yellow oil.

후처리

  1. extractionwas extracted with ethyl acetate
  2. washThe organic layer was washed with an aqueous saturated solution of sodium chloride
  3. dry with materialwas dried with anhydrous magnesium sulfate
  4. customThe resulting organic layer was evaporated under reduced pressure
  5. customto remove the solvent

출처 및 근거

ORD 기록
ord-5f8fa155e3e64a7bb4d8f6ea9166fbdd
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06627651B1

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