tert-Butyl acrylate → tert-butyl N-[3-(4-hydroxyphenyl)propyl]-beta-alaninate

HRID 1169630노트

반응식

HRID 1169630 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[C:12]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])(=[O:15])[CH:13]=[CH2:14]>CO>[OH:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][CH2:3][CH2:2][NH:1][CH2:14][CH2:13][C:12]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 15458tert-Butyl acrylateHCID 4574248HCID 4574248, 화합물

생성물 1

HCID 23121488tert-butyl N-[3-(4-hydroxyphenyl)propyl]-beta-alaninate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a methanol solution (25 mL) of 4-(3-aminopropyl)phenol (1.83 g), tert-butyl acrylate (1.7 mL) was added dropwise thereto at room temperature, followed by stirring at room temperature overnight. The reaction mixture was concentrated. The residue was purified by silica gel column chromatography (ethyl acetate→ethyl acetate:methanol=3:1) to give the title compound (1.55 g) having the following physical properties. TLC: Rf 0.24 (ethyl acetate:methanol 5:1);

후처리

  1. customat room temperature
  2. concentrationThe reaction mixture was concentrated
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate→ethyl acetate:methanol=3:1)

출처 및 근거

ORD 기록
ord-0fab8896541841cc802419e13b1774b8
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07825109B2

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