Malononitrile → 2-(2,5-Dichloro-benzylidene)-malononitrile

HRID 1170044

반응식

HRID 1170044 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH:4]=O.[C:11](#[N:15])[CH2:12][C:13]#[N:14].[OH-].[K+].O>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH:4]=[C:12]([C:11]#[N:15])[C:13]#[N:14]

참가 물질

5

반응물 3

HCID 8010MalononitrileHCID 807022,5-DichlorobenzaldehydeHCID 23719240Potassium hydroxide monohydrate

생성물 1

HCID 595516612-(2,5-Dichloro-benzylidene)-malononitrile수율 95%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2,5-dichlorbenzaldehyde (4.0 g, 0.0228 mole) in ethanol (6 ml) was added malononitrile (1.52 g, 0.0228 mole), followed by 100 μL of 10% KOH/H2O. The mixture was stirred at room temperature for 2 hrs and then filtered to give the title compound (4.82 g) in 95% yield. 1H-NMR (400 MHz, d6-DMSO): δ ppm 8.66 (s, 1H), 8.07 (d, J=2.0 Hz, 1H), 7.74 (s, 1H), 7.74 (s, 1H). MS [m+H] calc'd for C10H4Cl2N2, 223.0, 224.8; found 223.0, 224.8.

후처리

  1. filtrationfiltered

출처 및 근거

ORD 기록
ord-c677fd57d5914ce6bf9d65241eb13db1
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07825242B2

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