Hydrochloric Acid → 2-Chloro-4-phenyl-6-(phenylsulfanyl)-3,5-pyridinedicarbonitrile

HRID 1170062노트

반응식

HRID 1170062 반응식
N(OCCC(C)C)=O.N[C:10]1[C:15]([C:16]#[N:17])=[C:14]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:13]([C:24]#[N:25])=[C:12]([S:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:11]=1.[ClH:33]>C(#N)C.[Cu](Cl)Cl>[Cl:33][C:10]1[C:15]([C:16]#[N:17])=[C:14]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:13]([C:24]#[N:25])=[C:12]([S:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:11]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 41651072-Amino-4-phenyl-6-phenylsulfanylpyridine-3,5-dicarbonitrile

생성물 1

HCID 120183412-Chloro-4-phenyl-6-(phenylsulfanyl)-3,5-pyridinedicarbonitrile

시약·촉매·용매 2

HCID 24014Cupric Chloride촉매HCID 6342Acetonitrile용매

실험 절차

Under argon, 24.5 g (182 mmol) of anhydrous copper(II) chloride are suspended in 180 ml of acetonitrile, and 21.4 g (182 mmol) of isopentyl nitrite are then added dropwise. After 20 minutes of stirring at room temperature, 10 g (30.5 mmol) of 2-amino-4-phenyl-6-(phenylsulfanyl)-3,5-pyridinedicarbonitrile [Kambe et al., Synthesis, 531-533 (1981)] are added. The mixture is stirred at room temperature over the weekend. For work-up, 150 ml of 1 N hydrochloric acid are added to the mixture, the mixture is extracted 4× with dichloromethane and the organic phase is washed once with saturated sodium chloride solution, dried over magnesium sulfate and concentrated under reduced pressure. The residue is triturated with a little ethyl acetate and allowed to stand in a fridge for one hour. The crystals are filtered off with suction and washed with a little cold ethyl acetate and diethyl ether.

후처리

  1. stirringThe mixture is stirred at room temperature over the weekend
  2. extractionthe mixture is extracted 4× with dichloromethane
  3. washthe organic phase is washed once with saturated sodium chloride solution
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe residue is triturated with a little ethyl acetate
  7. waitto stand in a fridge for one hour
  8. filtrationThe crystals are filtered off with suction
  9. washwashed with a little cold ethyl acetate and diethyl ether

출처 및 근거

ORD 기록
ord-99e0b3326a584528ab474094fc61fcd4
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07825255B2

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