Glyceraldehyde → Benzyl 4,5-dihydroxy-2-pentenoate

HRID 1170653

반응식

HRID 1170653 반응식
[CH2:1]([OH:6])[CH:2]([OH:5])[CH:3]=O.[Br-].[CH2:8]([O:15][C:16]([CH2:18][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>O1C(CC)C1>[OH:5][CH:2]([CH2:1][OH:6])[CH:3]=[CH:18][C:16]([O:15][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:17]

참가 물질

4

반응물 2

HCID 751GlyceraldehydeHCID 11214019(Benzyloxycarbonylmethyl)triphenylphosphonium bromide

생성물 1

HCID 54529065Benzyl 4,5-dihydroxy-2-pentenoate

시약·촉매·용매 1

HCID 78341,2-Epoxybutane용매

실험 절차

A mixture of DL-glycerinaldehyde (4.5 g, 50 mmole) and (benzyloxycarbonylmethyl)-triphenyl-phosphoniumbromide (24.57 g, 50 mmole) in 100 ml 1,2-epoxybutane was refluxed overnight. The mixture was evaporated under vacuum and the product was isolated by silica gel column chromatography.

후처리

  1. temperaturewas refluxed overnight
  2. customThe mixture was evaporated under vacuum
  3. customthe product was isolated by silica gel column chromatography

출처 및 근거

ORD 기록
ord-5f272bfbdb2243eb8c4502e1ff98021d
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07825238B2

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