Hydrochloric Acid → (S)-mandelic acid

HRID 1171616

반응식

HRID 1171616 반응식
[C:1]([O-:11])(=[O:10])[C@@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].Cl>O>[C:1]([OH:11])(=[O:10])[C@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 5460269(R)-Mandelate2회

생성물 1

HCID 439616(S)-mandelic acid수율 57%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
1 °C

실험 절차

The L-mandelate (S,R,R salt 2, 274 g, 1.03 mol) was dissolved in water (400 ml) and brought to pH 1.5 by adding concentrated hydrochloric acid. The mixture was cooled to 1° C. and seeded by adding a few crystals of S-mandelic acid. The mixture was stirred at 0° C. for a further 2 hours and the precipitated crystal slurry was filtered with suction. The filter residue was washed with ice-water (100 ml) and dried at 50° C. under reduced pressure. 86 g (57%) of L-mandelic acid were obtained, which were optically pure according to analysis.

후처리

  1. filtrationthe precipitated crystal slurry was filtered with suction
  2. washThe filter residue was washed with ice-water (100 ml)
  3. customdried at 50° C. under reduced pressure

출처 및 근거

ORD 기록
ord-a33c80d9c77049f1ab953f801eddba31
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07829702B2

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