Benzoyl Peroxide → HCID 23139035, 화합물

HRID 1171661노트

반응식

HRID 1171661 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([CH:12]1[CH2:14][CH2:13]1)=[O:11].[Br:15]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:15][CH:9]([C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[F:1])[C:10]([CH:12]1[CH2:14][CH2:13]1)=[O:11]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 23138773853804-82-7

생성물 1

HCID 23139035HCID 23139035, 화합물수율 84.5%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

To a solution of 2-(2,4-difluorophenyl)-1-cyclopropylethanone (329 mg) in carbon tetrachloride (10 ml) was added N-bromosuccinimide (360 mg) and 75% benzoyl peroxide with stirring at room temperature, and the resulting mixture was refluxed for 3.5 hours. After the reaction mixture was filtrated, 1N aqueous sodium hydroxide solution was added to the filtrate. The resulting mixture was extracted with ethyl acetate, and the extract was washed with saturated sodium chloride solution. The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed in vacuo to afford the title compound (390 mg, yield: 84%) as a yellow oil.

후처리

  1. temperaturethe resulting mixture was refluxed for 3.5 hours
  2. filtrationAfter the reaction mixture was filtrated
  3. addition1N aqueous sodium hydroxide solution was added to the filtrate
  4. extractionThe resulting mixture was extracted with ethyl acetate
  5. washthe extract was washed with saturated sodium chloride solution
  6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  7. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-194ac7653146420b868ad286e5a3f138
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07829580B2

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