Malonic Acid → (r)-3-(p-Bromophenyl)-beta-alanine

HRID 1172043노트

반응식

HRID 1172043 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[C:10]([O-:13])(=[O:12])[CH3:11].[NH4+:14].C(O)(=O)CC(O)=O>C(O)C.O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C@@H:6]([CH2:11][C:10]([OH:13])=[O:12])[NH2:14])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 867Malonic AcidHCID 707414-BromobenzaldehydeHCID 517165Ammonium Acetate

생성물 1

HCID 724054(r)-3-(p-Bromophenyl)-beta-alanine수율 63%

시약·촉매·용매 1

HCID 19096565Water ethanol용매

반응 조건

온도
80 °C

실험 절차

p-Bromo-benzaldehyde (10.0 g, 54 mmol) was mixed with 100 ml of ethanol/water (95/5), 8.3 g of ammonium acetate (108 mmol), and 11.2 g of malonic acid (108 mmol), heated under reflux at 80° C. with stirring for 17 hours, filtered under heating and dried under reduced pressure to give 8.3 g of p-bromo-β-phenylalanine crystals at a yield of 62.8%.

후처리

  1. temperatureheated
  2. filtrationfiltered
  3. temperatureunder heating
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-e95d6e8a951d45208b34fdfc6c0133bb
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07833760B2

반응 노트

불러오는 중…