Water → (5-fluoro-1-phenyl-3-trifluoromethyl-1H-pyrazol-4-yl)-methanol

HRID 1172097노트

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HRID 1172097 반응식
[BH4-].[Na+].[F:3][C:4]1[N:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:7]=[C:6]([C:15]([F:18])([F:17])[F:16])[C:5]=1[CH:19]=[O:20].O>CO>[F:3][C:4]1[N:8]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:7]=[C:6]([C:15]([F:17])([F:16])[F:18])[C:5]=1[CH2:19][OH:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 178628865-fluoro-1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboaldehyde

생성물 1

HCID 17862906(5-fluoro-1-phenyl-3-trifluoromethyl-1H-pyrazol-4-yl)-methanol수율 106.9%

시약·촉매·용매 1

HCID 887Methanol용매2회

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온도
0 °C

실험 절차

To a solution of 1.6 g (41.0 mmoles) of sodium borohydride dissolved in 300 ml of methanol was added, with ice-cooling, a solution of 26.5 g (102.5 mmoles) of 5-fluoro-1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carboaldehyde dissolved in 200 ml of methanol. The resulting mixture was stirred at 0° C. for 30 minutes to give rise to a reaction. After the completion of the reaction, the reaction mixture was poured into water, followed by extraction with ethyl acetate. The resulting organic layer was washed with an aqueous sodium chloride solution and then dried over anhydrous magnesium sulfate. The resulting solution was subjected to vacuum distillation to remove the solvent contained therein, to obtain 28.5 g (yield: 100%) of (5-fluoro-1-phenyl-3-trifluoromethyl-1H-pyrazol-4-yl)-methanol.

후처리

  1. additionwas added, with ice-
  2. temperaturecooling
  3. customto give rise
  4. customto a reaction
  5. customAfter the completion of the reaction
  6. extractionfollowed by extraction with ethyl acetate
  7. washThe resulting organic layer was washed with an aqueous sodium chloride solution
  8. dry with materialdried over anhydrous magnesium sulfate
  9. distillationThe resulting solution was subjected to vacuum distillation
  10. customto remove the solvent

출처 및 근거

ORD 기록
ord-f41b75a68ce9430ba3a31f8d08393a93
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07833939B2

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