홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

7-Chloro-benzo[1,4]dioxin-2-one → 2-(4-Chloro-2-hydroxy-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

HRID 11722
노트
인쇄 미리보기

반응식

HRID 11722 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][CH2:9][C:8](=[O:11])[O:7][C:6]=2[CH:12]=1.[F:13][C:14]1[CH:27]=[CH:26][C:17]([CH2:18][N:19]2[CH2:24][CH2:23][NH:22][C@H:21]([CH3:25])[CH2:20]2)=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:9][C:8]([N:22]2[CH2:23][CH2:24][N:19]([CH2:18][C:17]3[CH:26]=[CH:27][C:14]([F:13])=[CH:15][CH:16]=3)[CH2:20][C@H:21]2[CH3:25])=[O:11])=[C:6]([OH:7])[CH:12]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 32553187-Chloro-benzo[1,4]dioxin-2-oneHCID 11600914(r)-1-(4-Fluorobenzyl)-3-methylpiperazine

생성물 1

HCID 696558562-(4-Chloro-2-hydroxy-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone수율 52.9%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
95 °C

실험 절차

To a solution of 7-chloro-benzo[1,4]dioxin-2-one (0.845 g, 4.81 mmol) in toluene (25 mL) was added (3R)-1-(4-fluoro-benzyl)-3-methyl-piperazine (1.003 g, 4.81 mmol). The resulting mixture was heated to 95° C. overnight. The reaction was cooled to ambient temperature, filtered and concentrated in vacuo. Chromatography on silica gel gave the title compound (˜1 g).

후처리

  1. temperatureThe reaction was cooled to ambient temperature
  2. filtrationfiltered
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-6326dfff423e40298d12cdfe41a6ac19
출처 데이터셋
uspto-grants-2006_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07098212B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트