Sodium Hydroxide → methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate

HRID 1172281

반응식

HRID 1172281 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[NH:7][C:8]2[C:13]([C:14]=1[C:15]([O:17][CH3:18])=[O:16])=[CH:12][CH:11]=[CH:10][CH:9]=2.[OH-].[Na+]>C1(C)C=CC=CC=1>[O:5]1[C:6]2=[C:14]([C:15]([O:17][CH3:18])=[O:16])[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:7]2[CH2:2][CH2:3][CH2:4]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 9816818Methyl 2-(3-chloropropoxy)indole-3-carboxylate

생성물 1

HCID 11746477methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate수율 93.2%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
40 °C

실험 절차

Methyl 2-(3-chloropropoxy)indole-3-carboxylate (5.0 g, 18.7 mmol) was added to a stirred mixture of 5.4 M aqueous M NaOH (3.8 ml) and toluene (50 ml) and heated at 40° C. for 4 h. The aqueous layer was separated and the organic layer washed with H2O (3×25 ml) while maintaining the temperature at 60° C. The organic solvent was evaporated in vacuo to leave the product as a white solid (4.0 g, 93.2%).

후처리

  1. customThe aqueous layer was separated
  2. washthe organic layer washed with H2O (3×25 ml)
  3. temperaturewhile maintaining the temperature at 60° C
  4. customThe organic solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-695822113de44527905d9f27fa1b9f91
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834010B2

연결된 노트

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