Isocaproaldehyde → Ethyl 6-methyl-3-oxoheptanoate

HRID 1172397노트

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HRID 1172397 반응식
[CH2:1]([O:3][C:4](=[O:8])[CH:5]=[N+]=[N-])[CH3:2].[Sn](Cl)Cl.[CH3:12][CH:13]([CH3:18])[CH2:14][CH2:15][CH:16]=[O:17]>ClCCl>[CH2:1]([O:3][C:4](=[O:8])[CH2:5][C:16](=[O:17])[CH2:15][CH2:14][CH:13]([CH3:18])[CH3:12])[CH3:2]

참가 물질

5

반응물 3

HCID 129IsocaproaldehydeHCID 12192Ethyl diazoacetateHCID 24479Stannous Chloride

생성물 1

HCID 15734035Ethyl 6-methyl-3-oxoheptanoate수율 55.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

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온도
25 °C

실험 절차

A solution of diazo-acetic acid ethyl ester (555 mg, 4.86 mmol) in dichloromethane (8 mL) was treated with tin (II) chloride (88 mg, 0.463 mmol) and stirred vigorously at 25° C. A solution of 4-methyl-pentanal (464 mg, 4.63 mmol) in dichloromethane (2 mL) was added to the mixture dropwise over 10 min resulting in gas evolution. After the nitrogen evolution ceased (approximately 1 h), the reaction was extracted with brine and diethyl ether (2×80 mL). The organic layers were combined, dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by flash column chromatography (ISCO RediSep column, 0 to 7% ethyl acetate in hexanes) to afford the desired product, 6-methyl-3-oxo-heptanoic acid ethyl ester (478 mg, 55%), as a light yellow oil. 1H NMR (400 MHz, CDCl3) δ: 0.89 (6H, d, J=6.3 Hz), 1.26-1.29 (4H, m), 1.48-1.57 (2H, m), 2.53 (2H, t, J=7.4 Hz), 3.42 (2H, s), 4.18 (2H, quartet, J=7.6 Hz).

후처리

  1. customresulting in gas evolution
  2. custom(approximately 1 h)
  3. extractionthe reaction was extracted with brine and diethyl ether (2×80 mL)
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe crude material was purified by flash column chromatography (ISCO RediSep column, 0 to 7% ethyl acetate in hexanes)

출처 및 근거

ORD 기록
ord-f78f64c805f04065b3e08ec066ec2bc5
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834009B2

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