Hydrochloric Acid → HCID 178479673, 화합물

HRID 1172445노트

반응식

HRID 1172445 반응식
[F:1][C:2]1[C:28]([C:29]([F:32])([F:31])[F:30])=[CH:27][CH:26]=[CH:25][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[CH:24]=[CH:23][NH:22][N:21]=3)[CH:16]=[N:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5].[ClH:33]>C(O)C>[ClH:33].[F:1][C:2]1[C:28]([C:29]([F:31])([F:30])[F:32])=[CH:27][CH:26]=[CH:25][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[CH:24]=[CH:23][NH:22][N:21]=3)[CH:16]=[N:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 178519567HCID 178519567, 화합물

생성물 1

HCID 178479673HCID 178479673, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

19.8 g of 6-((4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)-N-1H-pyrazol-3-ylpyrazin-2-amine (Example 44) was suspended in 200 ml of ethanol, and aqueous hydrogen chloride solution (1.0 M, 44.1 ml) was added thereto. The reaction mixture was stirred at room temperature for 1 hour and then evaporated. The resulting residue was solidified with 200 ml of heptane, evaporated and dried to give 6-((4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)-N-1H-pyrazol-3-ylpyrazin-2-amine hydrochloride.

후처리

  1. customevaporated
  2. customevaporated
  3. customdried

출처 및 근거

ORD 기록
ord-ad21d87a46894380a0a7b606a88b1a1a
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834018B2

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