Ethanol → 5-Iodo-4-(1-methylhydrazino)-2-methylthiopyrimidine
반응식
C(=O)([O-])[O-].[K+].[K+].C(O)C.Cl[C:11]1[C:16]([I:17])=[CH:15][N:14]=[C:13]([S:18][CH3:19])[N:12]=1.[CH3:20][NH:21][NH2:22]>O>[I:17][C:16]1[C:11]([N:21]([CH3:20])[NH2:22])=[N:12][C:13]([S:18][CH3:19])=[N:14][CH:15]=1참가 물질
6
실험 절차
603 mg of potassium carbonate was added to ethanol (15 mL) solution of 1.25 g of 4-chloro-5-iodo-2-(methylthio)pyrimidine, and with cooling with ice, 0.28 mL of methylhydrazine was dropwise added thereto. This was stirred overnight at room temperature, then water was added thereto, and the precipitated crystal was taken out through filtration and dried to obtain 851 mg of the entitled compound as a white solid.
후처리
- additionwas dropwise added
- filtrationthe precipitated crystal was taken out through filtration
- customdried
출처 및 근거
- ORD 기록
- ord-afb4fcc0216e4203ba49a5451e308fd5
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07834019B2
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